Appearance of macrolide-resistant Bordetella pertussis strains in China.
نویسندگان
چکیده
Zengguo Wang, Yarong Li, Tiejun Hou, Xiaoguai Liu, Ying Liu, Tongtong Yu, Zhijun Chen, Yuan Gao, Hengxin Li, Qiushui He Department of Vaccine-Preventable Diseases, Xi’an Center for Disease Control and Prevention, Xi’an, China; Number 3 Department of Infectious Diseases, Xi’an Children’s Hospital, Xi’an, China; National Institute for Communicable Disease Control and Prevention and State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, Changping, Beijing, China; Department of Medical Microbiology, Capital Medical University, Beijing, China; Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare (THL), Turku, Finland
منابع مشابه
Macrolide-Resistant Bordetella pertussis Infection in Newborn Girl, France
A macrolide antimicrobial drug was administered to a newborn with cough. On day 23 of hospitalization, macrolide-resistant Bordetella pertussis was isolated from nasopharyngeal aspirates. DNA sequencing and PCR-restriction fragment length polymorphism showed a 2047 A-to-G mutation in the 3 copies of the 23S rRNA gene. Monitoring for macrolide resistance is essential in infants <6 months of age.
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Pertussis is still endemic and the recently resurgence of the disease caused by Bordetella pertussis has been shown in many countries. The polymorphism of the virulence genes of B. pertussis and lack of any information about the allelic variation between the Iranian isolates promotes us to analysis of the genes encoded virulence factors including ptxS1, prn, fim3 and cya to understand the diffe...
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Introduction: Despite high level of vaccination against pertussis‚ whooping cough has re-emerged as a health threat, especially in infants. This could be related to expansion of Bordetella pertussis with novel alleles for virulence factors including the pertussis toxin promoter, ptxP3. Compared to ptxp1 strains‚ ptxp3 strains produce more pertussis toxin which results in immune supp...
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BACKGROUND Whooping cough was considered as one of the major causes of childhood morbidity and mortality worldwide. Resistant isolates of Bordetella pertussis to macrolides in some countries have been recently reported. OBJECTIVES Recent reports on macrolide-resistant B. pertussis isolates and lack of evidence for such resistance in clinical isolates of the Iranian patients led the authors of...
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Whooping cough (pertussis) is a highly contagious disease of the human respiratory tract, which is caused by Bordetella pertussis. Reemerge of pertussis in some highly immunized populations and divergency in gene order among several B. pertussis strains promoted this research to study the change of pertussis toxin (PT) and lipopolysacharide levels in response to the different environments. Th...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 57 10 شماره
صفحات -
تاریخ انتشار 2013